Chronic depletion of glutathione (GSH) and minimal modification of LDL in vivo: its prevention by glutathione mono ester (GME) therapy
نویسندگان
چکیده
منابع مشابه
Glutathione, Reduced (GSH) Monograph
Introduction Reduced glutathione, most commonly called glutathione or GSH, is a relatively small molecule ubiquitous in living systems. Occurring naturally in all human cells, GSH is a water-phase orthomolecule. Its intracellular depletion ultimately results in cell death and its clinical relevance has been researched for decades. GSH is the smallest intracellular thiol (–SH) molecule. Its high...
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Parkinson's disease (PD) is associated with loss of total glutathione (GSH) which may contribute to progressive cell death. Peripheral GSH administration has been used clinically with reported benefits. Despite this, there is little specific information to characterize its cellular uptake or clearance, brain elevation with peripheral delivery or neuroprotective efficacy in PD models. The curren...
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Glutathione in its reduced form (GSH) is an antioxidant and also is involved in pheomelanin formation. Thus, it has been long believed that GSH has a skin whitening effect. However, its actual or direct effect is unproven. We evaluated the anti-melanogenic effects of GSH and its derivatives in vitro. We examined change of melanogenesis and its related proteins by GSH itself and its derivatives,...
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Glutathione is not effectively transported into human lymphoid cells, normal human skin fibroblasts, and fibroblasts from patients with genetic deficiencies of gamma-glutamylcysteine synthetase or glutathione synthetase. On the other hand, the monoethyl ester of glutathione, in which the carboxyl group of the glycine residue is esterified, is readily transported into these cells and is hydrolyz...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
سال: 2005
ISSN: 0925-4439
DOI: 10.1016/j.bbadis.2004.11.025